The gameplay strongly resembles that of Killzone 2 albeit with several tweaks and changes. Similar to the first Killzone, the game takes place in various harsh environments such as Arctic landscapes, a lethal alien jungle, nuclear wastelands as well as space battles rather than only the city-scape environments which were present in Killzone 2. Another notable new feature is the ability to use jet packs in the game, which were also used in Killzone: Liberation.
The game also features a revamped close combat melee system (called Brutal Melee) which includes new brutal melee attacks as well as the ability to string together multiple attacks in a combo. A new weapon called the WASP has also been added, which acts as a multi-firing rocket launcher firing in spiral formation.