In Birmingham, Alabama, a woman called Evelyn goes to a nursing home to visit her mother-in-law and meets an elderly woman called Ninny. They become friends. Ninny tells Evelyn stories about when she was younger, and about the people she used to know. In particular, she tells Evelyn about two young women, Idgie and Ruth.
In Ninny's stories, Idgie and Ruth are friends who run a café together and raise Ruth's son Buddy. Ruth has separated from her husband Frank because he used to hit her. One day, Frank goes missing and the police begin to think that Idgie has killed him.
Ninny tells Evelyn her stories over several visits. During that time, Evelyn, who was depressed, is inspired by Ruth and Idgie to have more power in her life. In the end, Ninny goes to live with Evelyn and her husband. There is a hint that Ninny and Idgie might be the same person.